Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins.

The challenges posed by COVID-19's emergence have led to a search for its therapies. There is no cure for COVID-19 infection yet, but there is significant progress in vaccine formulation for prophylaxis and drug development (such as Paxlovid) for high-risk patients. As a contribution to the ongoing quest for solutions, this study shows potent phytocompounds identification as inhibitors of SARS-CoV-2 targets using in silico methods. We used virtual screening, molecular docking, and molecular dynamics (MD) simulations to investigate the interaction of some phytochemicals with 3CLpro, ACE2, and PLpro proteins crucial to the SARS-CoV-2 viral cycle. The predicted docking scores range from -5.5 to -9.4 kcal/mol, denoting appreciable binding of these compounds to the SARS-CoV-2 proteins and presenting a multitarget inhibition for COVID-19. Some phytocompounds interact favorably at non-active sites of the enzymes. For instance, MD simulation shows that an identified site on PLpro is stable and likely an allosteric region for inhibitor binding and modulation. These phytocompounds could be developed into effective therapy against COVID-19 and probed as potential multitarget-directed ligands and drug candidates against the SARS-CoV-2 virus. The study unveils drug repurposing, selectivity, allosteric site targeting, and multitarget-directed ligand in one piece. These concepts are three distinct approaches in the drug design and discovery pipeline.

Women’s childbirth expectations and perceived effects of COVID-19 protocols on delivery

Aim: The study assessed women’s childbirth expectations and perceived effects of COVID-19 protocols on delivery in selected healthcare facilities in Umuahia, Abia State, Nigeria. Methods: The study adopted a cross-sectional descriptive survey research design. 304 women were purposively recruited from March through December 2020 from selected healthcare facilities in Umuahia. A validated researcher-developed questionnaire was used as instrument for data collection. Data obtained were subjected to descriptive statistics of frequencies, means, and standard deviations. Results: Major findings showed highly rated expectations of women during childbirth were women’s involvement in decision making about their care (3.69 ± 3.20), provision of adequate information on baby care (3.65 ± 3.17), and positive attitude of healthcare providers (3.59 ± 3.11). A greater number of the participants strongly agreed that COVID-19 lockdown led to severe labor outcomes (3.25 ± 2.98) and delays in observing COVID-19 protocols by skilled personnel during delivery pose a great threat to mother and baby (3.58 ± 3.12). On the other hand, observation of social distancing by midwives (1.57 ± 1.28) and testing women for COVID-19 before admission (1.96 ± 1.58) did not have any negative effect on the women’s delivery. Conclusions: Women’s involvement in decision making concerning their birth plans and care are among the women’s expectations for their birth. Healthcare providers need to fully understand these expectations and provide care that is consistent with them. It is also essential that information provided to antenatal women, especially during pandemics, is comprehensive and comprehensible. This should be used to openly communicate issues that may impact their birth experience, particularly in pandemics. © 2022 The Authors.

Veterans' ambulatory care experience during COVID-19: veterans' access to and satisfaction with primary care early in the pandemic.

BACKGROUND: The COVID-19 pandemic caused widespread changes to healthcare, but few studies focus on ambulatory care during the early phase of the pandemic. We characterize veterans' ambulatory care experience, specifically access and satisfaction, early in the pandemic. METHODS: We employed a semi-structured telephone interview to capture quantitative and qualitative data from patients scheduled with a primary care provider between March 1 - June 30, 2020. Forty veterans were randomly identified at a single large urban Veterans Health Administration (VHA) medical center. The interview guide utilized 56 closed and open-ended questions to characterize veterans' perceptions of access to and satisfaction with their primary care experience at VHA and non-VHA primary care sources. We also explored the context of veterans' daily lives during the pandemic. We analyzed quantitative data using descriptive statistics and verbatim quotes using a matrix analysis. RESULTS: Veterans reported completing more appointments (mean 2.6 (SD 2.2)) than scheduled (mean 2.3 (SD 2.2)) mostly due to same-day or urgent visits, with a shift to telephone (mean 2.1 (SD 2.2)) and video (mean 1.5 (SD 0.6)). Among those who reported decreased access to care early in the pandemic (n = 27 (67%)), 15 (56%) cited administrative barriers ("The phone would hang up on me") and 9 (33%) reported a lack of provider availability ("They are not reaching out like they used to"). While most veterans (n = 31 (78%)) were highly satisfied with their VHA care (mean score 8.6 (SD 2.0 on a 0-10 scale), 9 (23%) reported a decrease in satisfaction since the pandemic. The six (15%) veterans who utilized non-VHA providers during the period of interest reported, on average, higher satisfaction ratings (mean 9.5 (SD 1.2)). Many veterans reported psychosocial effects such as the worsening of mental health (n = 6 (15%)), anxiety concerning the virus (n = 12 (30%)), and social isolation (n = 8 (20%), "I stay inside and away from people"). CONCLUSIONS: While the number of encounters reported suggest adequate access and satisfaction, the comments regarding barriers to care suggest that enhanced approaches may be warranted to improve and sustain veteran perceptions of adequate access to and satisfaction with primary care during times of crisis.

The COVID-19 Pandemic: How Pastors Communicate Faith and Hope to Virtual Congregations

This paper examines how pastors engaged an online presence to preach the Word of God and address the needs of their congregations, during the crisis of the Covid-19 pandemic lockdown in South Africa. This is set against the Biblical instruction of Jesus Christ to Peter, to “feed my sheep” in John 21: 17, as it is the very same instruction that holds for pastors in churches today. However, the normal operations of the ministry have changed since the COVID-19 pandemic. The Christian church, a close-knit group of believers to whom social and physical distancing are foreign concepts, has had to adapt. Worship sites have been abandoned, and the absence of worshipers has become the norm. Pastoral ministries have been disrupted and call for pastors to embrace new technology to ensure that they have a digital presence with their congregation through social media. This paper argues that these circumstances give the church of God a unique opportunity to rethink how to continue ministry without physical contact. It adopted a mixed methods (qualitative and quantitative) approach, using an online questionnaire and telephonic surveys to engage pastors. The paper utilises the Two-way Communication Model (TCM) and the Uses and Gratification Theory (UGT). It concluded that pastoral care and spiritual counselling are essential in crises, that pastors have embraced social media in their mission, and that there is support for digital technology. The article recommendations that there should be a balanced communication strategy for Pastor’s ministries, and that government partners with faith-based organisations in different ways in a joint effort to combat the virus, while encouraging and supporting congregants © 2021 Open Access